Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.9
USERS' SCORE
Good
Based on 9 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Read More
9
We investigated the potential of vitamin B6, in the form of pyridoxal-5'-phosphate (PLP), to influence blood pressure, particularly in the context of hypertension. Our focus was on how PLP modifies angiotensin II, a peptide that plays a critical role in blood vessel constriction, transforming it into a different form known as pyruvamide-Ang II (Ang P).
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
Read More
9
We examined the effects of pyridoxamine, a vitamin B6 derivative, on heart damage caused by doxorubicin (DOX), a common chemotherapy drug known for its harmful impact on the heart. In our study, we used a rat model where some rats received DOX while others received a combination of DOX and pyridoxamine. We also included control groups for comparison to ensure the effectiveness of the treatment could be clearly evaluated.
Our findings showed that pyridoxamine significantly reduced the heart-related harm often associated with DOX treatment. Specifically, it helped in preserving the heart's structure and function, limiting the development of conditions like dilated cardiomyopathy. Furthermore, pyridoxamine appeared to mitigate inflammation, fibrosis, and oxidative stress, all of which can worsen heart health over time.
The treatment notably protected against iron-related cell death, restoring healthier balance in iron levels and improving overall heart condition at the genetic level. This suggests that pyridoxamine could serve as a promising new strategy to protect against heart damage in patients undergoing chemotherapy.
Our findings showed that pyridoxamine significantly reduced the heart-related harm often associated with DOX treatment. Specifically, it helped in preserving the heart's structure and function, limiting the development of conditions like dilated cardiomyopathy. Furthermore, pyridoxamine appeared to mitigate inflammation, fibrosis, and oxidative stress, all of which can worsen heart health over time.
The treatment notably protected against iron-related cell death, restoring healthier balance in iron levels and improving overall heart condition at the genetic level. This suggests that pyridoxamine could serve as a promising new strategy to protect against heart damage in patients undergoing chemotherapy.
Read More
Most Useful Reviews
9
Supports heart health
B12 and folate Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) merges the biologically active forms of vitamins B12, B9, and B6 to bolster cellular energy metabolism and neurotransmitter synthesis. This blend aids in converting homocysteine to methionine, promoting cardiovascular health.
Read More
7.5
Promotes cardiovascular health
B12 and folate Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) merges the biologically active forms of vitamins B12, B9, and B6 to bolster cellular energy metabolism and neurotransmitter synthesis. This blend aids in converting homocysteine to methionine, promoting cardiovascular health.
Read More
7.5
Supports cardiovascular health
Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) combines the active forms of vitamins B12, B9, and B6, aiding cellular energy metabolism and neurotransmitter synthesis. This combination helps convert homocysteine to methionine, supporting cardiovascular health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.9
- All Researches
9
We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Read More
9
We examined how vitamin B6, or pyridoxine, might help protect against cardiovascular issues, specifically focusing on its effects in a model of angina in rats. The study involved administering vasopressin, which induced heart stress and ischemia, helping us assess the protective capabilities of pyridoxine.
During testing, we found that vitamin B6 effectively reduced ST-segment elevation on ECG and lowered heart rate related to the vasopressin-induced angina. Notably, it showed a dose-dependent response, with specific doses of 5 mg and 7 mg per kilogram proving particularly effective.
Interestingly, when we compared pyridoxine to amlodipine, another cardiovascular drug, we observed that pyridoxine not only performed better at reducing cardiac enzymes linked to heart damage but also suggests a novel approach to preventing coronary heart disease. However, combining pyridoxine with amlodipine raised concerns about increased adverse cardiovascular events, indicating that while pyridoxine may enhance heart protection, pairing it with certain medications could complicate treatment.
Given these findings, we believe that vitamin B6 at optimal doses may hold promise for heart disease prevention and deserves further exploration in clinical settings.
During testing, we found that vitamin B6 effectively reduced ST-segment elevation on ECG and lowered heart rate related to the vasopressin-induced angina. Notably, it showed a dose-dependent response, with specific doses of 5 mg and 7 mg per kilogram proving particularly effective.
Interestingly, when we compared pyridoxine to amlodipine, another cardiovascular drug, we observed that pyridoxine not only performed better at reducing cardiac enzymes linked to heart damage but also suggests a novel approach to preventing coronary heart disease. However, combining pyridoxine with amlodipine raised concerns about increased adverse cardiovascular events, indicating that while pyridoxine may enhance heart protection, pairing it with certain medications could complicate treatment.
Given these findings, we believe that vitamin B6 at optimal doses may hold promise for heart disease prevention and deserves further exploration in clinical settings.
Read More
9
We investigated the potential of vitamin B6, in the form of pyridoxal-5'-phosphate (PLP), to influence blood pressure, particularly in the context of hypertension. Our focus was on how PLP modifies angiotensin II, a peptide that plays a critical role in blood vessel constriction, transforming it into a different form known as pyruvamide-Ang II (Ang P).
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
Read More
9
We set out to understand whether vitamin B-6 has preventive effects on heart failure with preserved ejection fraction (HFpEF), a condition often associated with changes in heart macrophages. To test this, we used a mouse model where we induced HFpEF through a combination of a high-fat diet and a specific supplement.
By assessing the cardiac function using echocardiography, we were able to track how the inclusion of vitamin B-6 impacted various heart issues related to HFpEF. Our findings were quite promising: when vitamin B-6 was administered alongside the HFpEF diet, we saw significant improvements in several key areas.
The E/E' ratio—a measure of heart function—dropped considerably, from 42.0 down to 21.6, while the E/A ratio improved, indicating better heart operation. Moreover, the mice displayed enhanced exercise capacity. However, it was interesting to note that these positive outcomes vanished in mice lacking the DOK3 protein, suggesting that vitamin B-6 plays a role in regulating signaling pathways that affect the function of heart macrophages.
Overall, our study indicates that vitamin B-6 could be a valuable therapeutic approach to mitigate the effects of HFpEF by preventing harmful changes in macrophage function, thereby supporting heart health.
By assessing the cardiac function using echocardiography, we were able to track how the inclusion of vitamin B-6 impacted various heart issues related to HFpEF. Our findings were quite promising: when vitamin B-6 was administered alongside the HFpEF diet, we saw significant improvements in several key areas.
The E/E' ratio—a measure of heart function—dropped considerably, from 42.0 down to 21.6, while the E/A ratio improved, indicating better heart operation. Moreover, the mice displayed enhanced exercise capacity. However, it was interesting to note that these positive outcomes vanished in mice lacking the DOK3 protein, suggesting that vitamin B-6 plays a role in regulating signaling pathways that affect the function of heart macrophages.
Overall, our study indicates that vitamin B-6 could be a valuable therapeutic approach to mitigate the effects of HFpEF by preventing harmful changes in macrophage function, thereby supporting heart health.
Read More
9
Vitamin B6 shows uncertain cardiovascular effects
We conducted a study to assess the potential benefits of vitamin B6, along with other B vitamins, in lowering homocysteine levels and reducing bad cholesterol (LDL-C) in individuals at risk for cardiovascular disease due to specific genetic polymorphisms.
Our research included a randomized, double-blind, placebo-controlled trial with 54 participants aged between 40 and 75, all of whom had elevated homocysteine and moderate LDL-C levels. Over a six-month period, those receiving a combination of methylfolate, pyridoxal-5'-phosphate (vitamin B6), and methylcobalamin showed a significant reduction in both homocysteine by 30% and LDL-C by 7.5%, compared to those who received a placebo.
Particularly interesting were the findings regarding the subgroup of participants with homozygous minor allele polymorphisms, who experienced even larger decreases in homocysteine levels and LDL-C compared to mixed allele carriers. While vitamin B6 was part of the effective combination, we must note that its individual effect on cardiovascular disease remains uncertain, as the study primarily evaluates the combined effect of the B vitamins.
Our research included a randomized, double-blind, placebo-controlled trial with 54 participants aged between 40 and 75, all of whom had elevated homocysteine and moderate LDL-C levels. Over a six-month period, those receiving a combination of methylfolate, pyridoxal-5'-phosphate (vitamin B6), and methylcobalamin showed a significant reduction in both homocysteine by 30% and LDL-C by 7.5%, compared to those who received a placebo.
Particularly interesting were the findings regarding the subgroup of participants with homozygous minor allele polymorphisms, who experienced even larger decreases in homocysteine levels and LDL-C compared to mixed allele carriers. While vitamin B6 was part of the effective combination, we must note that its individual effect on cardiovascular disease remains uncertain, as the study primarily evaluates the combined effect of the B vitamins.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports heart health
B12 and folate Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) merges the biologically active forms of vitamins B12, B9, and B6 to bolster cellular energy metabolism and neurotransmitter synthesis. This blend aids in converting homocysteine to methionine, promoting cardiovascular health.
Read More
7.5
Promotes cardiovascular health
B12 and folate Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) merges the biologically active forms of vitamins B12, B9, and B6 to bolster cellular energy metabolism and neurotransmitter synthesis. This blend aids in converting homocysteine to methionine, promoting cardiovascular health.
Read More
7.5
Supports cardiovascular health
Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) combines the active forms of vitamins B12, B9, and B6, aiding cellular energy metabolism and neurotransmitter synthesis. This combination helps convert homocysteine to methionine, supporting cardiovascular health.
Read More
7.5
Supports cardiovascular health
Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) combines the active forms of vitamins B12, B9, and B6, aiding cellular energy metabolism and neurotransmitter synthesis. This combination helps convert homocysteine to methionine, supporting cardiovascular health.
Read More
7.5
Supports cardiovascular health
Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) combines the active forms of vitamins B12, B9, and B6, aiding cellular energy metabolism and neurotransmitter synthesis. This combination helps convert homocysteine to methionine, supporting cardiovascular health.
Read More
Frequently Asked Questions
7.5
Promotes cardiovascular health
B12 and folate Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) merges the biologically active forms of vitamins B12, B9, and B6 to bolster cellular energy metabolism and neurotransmitter synthesis. This blend aids in converting homocysteine to methionine, promoting cardiovascular health.
7.5
Supports cardiovascular health
Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) combines the active forms of vitamins B12, B9, and B6, aiding cellular energy metabolism and neurotransmitter synthesis. This combination helps convert homocysteine to methionine, supporting cardiovascular health.
7.5
Supports cardiovascular health
Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) combines the active forms of vitamins B12, B9, and B6, aiding cellular energy metabolism and neurotransmitter synthesis. This combination helps convert homocysteine to methionine, supporting cardiovascular health.
7.5
Supports cardiovascular health
Jarrow Formulas® Methyl B12 & Methylfolate with Pyridoxal-5-Phosphate (P-5-P) combines the active forms of vitamins B12, B9, and B6, aiding cellular energy metabolism and neurotransmitter synthesis. This combination helps convert homocysteine to methionine, supporting cardiovascular health.
7
We investigated the connection between blood pressure variability (BPV) and vitamin B6 and B12 levels in individuals with essential hypertension. Our study involved 100 patients with hypertension and a control group of 100 healthy individuals.
We found that patients with hypertension had significantly lower levels of these B vitamins compared to the healthy group. Additionally, those with higher B vitamin levels exhibited reduced BPV.
This suggests that Vitamin B6 and B12 may influence blood pressure control, providing insights into hypertension management strategies.
We found that patients with hypertension had significantly lower levels of these B vitamins compared to the healthy group. Additionally, those with higher B vitamin levels exhibited reduced BPV.
This suggests that Vitamin B6 and B12 may influence blood pressure control, providing insights into hypertension management strategies.
9
We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
8
We aimed to understand how levels of Pyridoxal 5'-Phosphate (PLP), the active form of vitamin B6, relate to lipid profiles and potentially impact cardiovascular health. Using data from a large, population-based survey involving adults aged 20 and older, we conducted a thorough analysis of the relationships between PLP levels and cholesterol types, like LDL (bad) and HDL (good) cholesterol.
Our results showed that higher PLP levels were associated with lower levels of LDL cholesterol, suggesting that vitamin B6 might play a role in reducing the risk of cardiovascular issues. In fact, a single unit increase in PLP was linked to a significant decrease of around 17.7% in LDL cholesterol levels. Additionally, we found that PLP levels were positively correlated with HDL cholesterol levels, indicating that higher PLP could lead to an improvement in good cholesterol.
Notably, these associations seemed stronger in specific groups, such as diabetic individuals and those who abstain from alcohol. This points to a potential for vitamin B6 supplementation as a preventive measure against cardiovascular and metabolic diseases, particularly for those at higher risk. Overall, our findings illuminate vitamin B6 as a promising player in heart health discussions, particularly through its effects on cholesterol levels.
Our results showed that higher PLP levels were associated with lower levels of LDL cholesterol, suggesting that vitamin B6 might play a role in reducing the risk of cardiovascular issues. In fact, a single unit increase in PLP was linked to a significant decrease of around 17.7% in LDL cholesterol levels. Additionally, we found that PLP levels were positively correlated with HDL cholesterol levels, indicating that higher PLP could lead to an improvement in good cholesterol.
Notably, these associations seemed stronger in specific groups, such as diabetic individuals and those who abstain from alcohol. This points to a potential for vitamin B6 supplementation as a preventive measure against cardiovascular and metabolic diseases, particularly for those at higher risk. Overall, our findings illuminate vitamin B6 as a promising player in heart health discussions, particularly through its effects on cholesterol levels.
7
Vitamin B6 linked to lower mortality
We explored how vitamin B6, along with other vitamins, influences cardiovascular disease (CVD) and overall mortality among individuals with prediabetes. The study analyzed data from 14,634 prediabetes patients collected between 1999 and 2018, tracking their health outcomes until the end of 2019.
What we found is quite compelling: vitamin B6 levels showed a clear negative association with the risk of all-cause, CVD, and other types of mortality. In simpler terms, higher levels of vitamin B6 appear to correlate with a lower risk of dying from cardiovascular issues.
However, it's essential to acknowledge that while vitamin B6 has shown promising results, the study evaluated multiple vitamins simultaneously. This means that while we can be optimistic about vitamin B6’s effects, it wasn't the only focus of the investigation, and other vitamins like B1, niacin, folate, vitamin C, vitamin E, and vitamin K also played significant roles in lowering mortality risks.
Overall, increasing vitamin B6 intake could be beneficial for those with prediabetes looking to mitigate their cardiovascular risks, but it shouldn't be viewed in isolation. Ensuring a well-rounded intake of various vitamins is key to promoting better health outcomes.
What we found is quite compelling: vitamin B6 levels showed a clear negative association with the risk of all-cause, CVD, and other types of mortality. In simpler terms, higher levels of vitamin B6 appear to correlate with a lower risk of dying from cardiovascular issues.
However, it's essential to acknowledge that while vitamin B6 has shown promising results, the study evaluated multiple vitamins simultaneously. This means that while we can be optimistic about vitamin B6’s effects, it wasn't the only focus of the investigation, and other vitamins like B1, niacin, folate, vitamin C, vitamin E, and vitamin K also played significant roles in lowering mortality risks.
Overall, increasing vitamin B6 intake could be beneficial for those with prediabetes looking to mitigate their cardiovascular risks, but it shouldn't be viewed in isolation. Ensuring a well-rounded intake of various vitamins is key to promoting better health outcomes.
References
- Bian XY, Cui C, Zhang QY. Relationship between blood pressure variability and vitamin B level in essential hypertension. J Physiol Pharmacol. 2025;76. doi:10.26402/jpp.2025.1.02
- Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. doi:10.1016/j.ejphar.2025.177413
- Song Y, Choi JE, Park JM, Kwon YJ, Hong KW, et al. Genome-Wide Approach of Gene-Nutrient Intake Interaction Study for Essential Hypertension in a Large Korean Cohort (KoGES). Nutrients. 2024;16. doi:10.3390/nu16234147
- Palchetti CZ, Gonçalves NG, Suemoto CK, Santos IS, Lotufo PA, et al. Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification. Clin Nutr ESPEN. 2025;65:144. doi:10.1016/j.clnesp.2024.11.034
- Lin L, Chen S, Zhang C, Li L, Chen Y, et al. Association of dietary niacin intake with all-cause and cardiovascular mortality: National Health and Nutrition Examination Survey (NHANES) 2003-2018. Sci Rep. 2024;14:28313. doi:10.1038/s41598-024-79986-9
- Zhang RY, Chen Y, Yan XQ, Zhang Y, Zhou H, et al. Association of pyridoxal 5'-phosphate (PLP) with lipid profiles: a population-based cohort study. Front Nutr. 2025;12:1545301. doi:10.3389/fnut.2025.1545301
- Al-Khawlani MA, Al-Madhagi WM, Sabati AM, ALomaisi SAMA, Al-Najar M. Protective effects of pyridoxine, amlodipine, and their combination in a vasopressin-induced angina model in rats. Naunyn Schmiedebergs Arch Pharmacol. 2025. doi:10.1007/s00210-025-03905-6
- Lellig M, Rodríguez M, López-Baltanás R, Hermann J, Wollenhaupt J, et al. Pyridoxal-5'-phosphate: A cost-effective treatment candidate for hypertensive patients?. J Intern Med. 2024;296:435. doi:10.1111/joim.20015
- Rafinezhad M, Kheirouri S, Abbasnezhad M, Alizadeh M. What Dietary Vitamins and Minerals Might Be Associated with Paraoxonase-1 Serum Levels in Patients with Coronary Artery Disease?. Biol Trace Elem Res. 2024. doi:10.1007/s12011-024-04382-3
- Ren W, Li Y, Lu C, Liu S, Shao Y, et al. Comprehensive assessment on the association of dietary vitamins with all-cause and cardiovascular mortality among individuals with prediabetes: evidence from NHANES 1999-2018. Food Funct. 2024;15:10037. doi:10.1039/d4fo02893g
- Dong G, Xu W, Xu L. Causal Effect of Macronutrient and Micronutrient Intake on Stroke: A Two-Sample Mendelian Randomization Study. Nutrients. 2024;16. doi:10.3390/nu16172818
- Li B, Hu M, Ma Y, Sun X, Wu D, et al. Association between Vitamin E, Vitamin B6, and Vitamin B12 with coronary heart disease. Sci Rep. 2024;14:19960. doi:10.1038/s41598-024-68413-8
- Song JW, Zhang ZS, Chen L, Wang QW, Xu JY, et al. Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model. J Nutr. 2024;154:3031. doi:10.1016/j.tjnut.2024.08.006
- Pokushalov E, Ponomarenko A, Bayramova S, Garcia C, Pak I, et al. Effect of Methylfolate, Pyridoxal-5'-Phosphate, and Methylcobalamin (Soloways) Supplementation on Homocysteine and Low-Density Lipoprotein Cholesterol Levels in Patients with Methylenetetrahydrofolate Reductase, Methionine Synthase, and Methionine Synthase Reductase Polymorphisms: A Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16111550
- Wang P, Huang J, Xue F, Abuduaini M, Tao Y, et al. Associations of serum vitamin B6 status with the risks of cardiovascular, cancer, and all-cause mortality in the elderly. Front Immunol. 2024;15:1354958. doi:10.3389/fimmu.2024.1354958
- Haesen S, Verghote E, Heeren E, Wolfs E, Deluyker D, et al. Pyridoxamine Attenuates Doxorubicin-Induced Cardiomyopathy without Affecting Its Antitumor Effect on Rat Mammary Tumor Cells. Cells. 2024;13. doi:10.3390/cells13020120
- Haesen S, Jager MM, Brillouet A, de Laat I, Vastmans L, et al. Pyridoxamine Limits Cardiac Dysfunction in a Rat Model of Doxorubicin-Induced Cardiotoxicity. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13010112
- Liang Z, Fan F, Liu B, Li K, Chen H, et al. Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses. Nutrients. 2024;17. doi:10.3390/nu17010159
- Prasad K. Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment. Int J Angiol. 2024;33:262. doi:10.1055/s-0044-1788280
- Kaushik A, Bhattacharjee D, Chaudhary V, Dahal S, Devi NK, et al. Hypertension and global DNA methylation: a population-based study in rural, Punjab, India. Sci Rep. 2024;14:25826. doi:10.1038/s41598-024-77437-z
- Siddiqi SM, Liu L, Du Y, Song Y, Chen P, et al. Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension. J Nutr. 2024. doi:10.1016/j.tjnut.2024.09.003
- Liang X, Huang D, Bi Y, He Y, Mao T, et al. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study. J Hum Hypertens. 2024;38:844. doi:10.1038/s41371-024-00955-w
